Integrated Biology Platform
Delivering comprehensive solutions from early discovery through IND-enabling translational studies
Mechanistic Assays
Mechanism-focused assay systems enabling precise evaluation of target engagement, structural characterization, and intracellular signaling pathway modulation. Supports MoA elucidation and translational pharmacology decision-making in oncology and immunology.
Structural Analysis & Molecular Interaction
Structural biology
- X-ray crystallography — co-crystal structure determination for binding site mapping and SAR interpretation
- NMR spectroscopy (via partner labs) — structural and dynamic analysis in solution; fragment-based screening support
Molecular interaction
- SPR (Surface Plasmon Resonance) — real-time binding kinetics: kon, koff, KD
- MST (Microscale Thermophoresis) — affinity measurement in solution under near-native conditions
- ITC (Isothermal Titration Calorimetry) — thermodynamic profiling: ΔH, ΔS, binding stoichiometry
Signaling & Pathway Analysis
Western blot-based ayalysis
- Phosphorylation marker profiling: pERK, pAKT, pSTAT, and additional pathway nodes
- Time- and dose-dependent pathway modulation analysis
- Western blot-based target protein degradation analysis (PROTAC/TPD workflows)
- Quantitative pathway profiling to support MoA differentiation and structure-activity relationships
Targeted protein degradation (TPD) readouts
- HiBiT-based quantitative degradation assays — real-time, high-sensitivity measurement
- Differentiation of inhibition vs. degradation mechanisms at the cellular level
- PROTAC/TPD lead optimization and candidate selection support
Kinase profiling & selectivity panels
- 79 TK (tyrosine kinase) panel
- 29 CDK (cyclin dependent kinase)/Cyclin combination panel
- 273 wild-type kinase panel
- 364 wild-type and clinically relevant mutants kinase panel
- Custom panel design tailored to project-specific selectivity needs
Reprogramming Cells, Empowering Medicine
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