Integrated Biology Platform
Delivering comprehensive solutions from early discovery through IND-enabling translational studies
Peptide Screening (mRNA)
Peptide Screening (mRNA Display Platform)
High-diversity peptide discovery platform enabling rapid identification of target-specific binders.
Library formats
- Massively large library: 10¹² to 10¹⁵ unique members — maximizing hit probability against challenging targets
- Diverse peptide formats: A broad selection of linear and monocyclic peptides is available, with lengths ranging from 8, 10, 12, 14, to 16 amino acids
- Custom synthesis libraries available for project-specific sequence requirements
Advanced Services
- Affinity maturation — iterative hit optimization to improve binding potency and selectivity
- Medicinal chemistry modifications (via partner labs):
◦ Incorporation of post-translational modifications (e.g., phosphorylation, acetylation)
◦ Integration of non-natural amino acids to expand chemical diversity and stability
◦ Peptide optimization for improved potency, stability, and developability
Functional Validation & Characterization
- Binding validation using biophysical methods (e.g., SPR, MST, ITC) for affinity and kinetics
- Functional assays tailored to mechanism, including:
◦ Protein–protein interaction (PPI) blockade
◦ Cellular internalization and uptake studies
◦ Cytotoxicity and proliferation assays
◦ Pathway modulation and signaling analysis
- Validation across biochemical and cellular systems to confirm specificity and activity
Reprogramming Cells, Empowering Medicine
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