Integrated Biology Platform
Delivering comprehensive solutions from early discovery through IND-enabling translational studies
Protein & Cell Biology
Foundational biological resources underpinning all downstream assay workflows — from recombinant protein production through to a comprehensive collection of engineered, cancer, and patient-derived cell models.
Protein Production
Expression systems
- Recombinant protein expression across E. coli, insect, and mammalian systems
- Construct design and optimization for activity, stability, and structural studies
- Support for wild-type and clinically relevant mutant proteins
- Scalable production tailored to screening, biophysics, and structural workflows
Purification methods
- Affinity chromatography (His-tag, GST, Strep-tag, protein A/G, and others)
- Ion exchange chromatography (IEX) for charge-based separation and polishing
- Size-exclusion chromatography (SEC) for final polishing and quality assessment
- Multi-step customized purification strategies for complex or low-yield targets
Cell Bank Resources
Cell line construction
- CRISPR/Cas9 genome editing — knockout, knock-in, and point mutation models
- Lentiviral stable cell line generation for long-term and in vivo-relevant studies
- Transient expression systems for rapid early-stage compound screening
- Endogenous protein tagging: HiBiT and GFP fusions for real-time quantification
- Reporter cell line development for pathway activity and transcriptional readouts
Cell line banks
- 400+ Ba/F3 cell lines covering 70+ kinases and resistance mutations
- 800+ cancer cell lines across solid and hematological malignancies
- 100+ engineered cell models (CRISPR-based, tagged, and reporter lines)
- 150+ patient-derived primary cell (PDC) models
- 1,000+ patient-derived organoids (PDOs) across diverse tumor types
Reprogramming Cells, Empowering Medicine
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