Integrated Biology Platform

Delivering comprehensive solutions from early discovery through IND-enabling translational studies

Autoimmune & Inflammatory Diseases

Well-established and mechanistically relevant in vivo disease models for evaluating immunomodulatory therapies, supporting pharmacodynamic characterization, efficacy assessment, and translational studies across major immune-mediated indications.

Rheumatoid arthritis

  • CIA — Collagen-Induced Arthritis model
  • CAIA — Collagen Antibody-Induced Arthritis model

Psoriasis

  • IMQ (imiquimod)-induced psoriasis model
  • IL-23-driven psoriasis model

Inflammatory bowel disease (IBD)

  • DSS-induced colitis model
  • TNBS-induced colitis model
  • CD4+ T cell transfer colitis model

Systemic lupus erythematosus (SLE)

  • MRL/lpr spontaneous model
  • Induced SLE models

Atopic dermatitis & hypersensitivity

  • OXA-induced, DNFB-induced, and MC903-induced models

Applications

  • Pharmacodynamic and efficacy evaluation of immunotherapies
  • Mechanism of action (MoA) studies in immune-mediated diseases
  • Biomarker identification and translational correlation
  • IND-enabling efficacy and proof-of-concept studies

Integrated Biology

Reprogramming Cells, Empowering Medicine

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